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     31-10 Thomson Avenue
          L.I.C, NY 11104
          M204
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    (718) 482-5940
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  • Research Interest of Professor Howard K. Motoike, Ph.D.

    My research involves the structure and function of mammalian voltage gated ion channels. I have been formally trained as a protein biochemist and molecular biologist to apply these techniques to study the role of different sodium, calcium and potassium channels with their associated proteins in numerous tissues such as skeletal muscle and the heart.

    Highlights from my research career include the first isolation of the ternary complex involving the dihydropyridine receptor, the ryanodine receptor and triadin from triad junctions of skeletal muscle; the demonstration that a region in the IVS5 segment of the cardiac calcium channel is critical in the use-dependent block by phenylalkylamines and benzothiazepines; and the demonstration that the carboxyl terminus of the cardiac sodium channel interacts with the III-IV intracellular linker demonstrating its involvement in channel inactivation.

    My most recent endeavors involve the structure and function of the voltage gated and calcium activated potassium channel also known as the Maxi K or BK channel. Most of my research activities occur at Columbia University but I am developing proposals for research projects at LaGuardia Community College.

    I have published in a variety of journals such as Science, The Journal of Biological Chemistry, The Journal of General Physiology, The Journal of Neuroscience, Cardiovascular Research and PNAS. I have mentored numerous students that ranged from high school, community colleges, senior colleges to those of medical and graduate schools.


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