Research Interests of Howard K. Motoike, Ph.D.
My research involves the structure and function of mammalian voltage
gated ion channels. I have been formally trained as a protein
biochemist and molecular biologist to apply these techniques to study
the role of different sodium, calcium and potassium channels with their
associated proteins in numerous tissues such as skeletal muscle and the
Highlights from my research career include the first isolation of the
ternary complex involving the dihydropyridine receptor, the ryanodine
receptor and triadin from triad junctions of skeletal muscle; the
demonstration that a region in the IVS5 segment of the cardiac calcium
channel is critical in the use-dependent block by phenylalkylamines and
benzothiazepines; and the demonstration that the carboxyl terminus of
the cardiac sodium channel interacts with the III-IV intracellular
linker demonstrating its involvement in channel inactivation.
My most recent endeavors involve the structure and function of the
voltage gated and calcium activated potassium channel also known as the
Maxi K or BK channel. Most of my research activities occur at Columbia
University but I am developing proposals for research projects at LaGuardia Community College.
I have published in a variety of journals such as Science, The
Journal of Biological Chemistry, The Journal of General Physiology, The
Journal of Neuroscience, Cardiovascular Research and PNAS.
I have mentored numerous students that ranged from high school,
community colleges, senior colleges to those of medical and graduate